| 环氧合酶-2与子宫内膜异位症血管形成相关性研究 |
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| 引用本文： | 冯晓娜,杜佳秋. 环氧合酶-2与子宫内膜异位症血管形成相关性研究[J]. 科学之友, 2011, 0(17) |
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| 作者姓名： | 冯晓娜 杜佳秋 |
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| 作者单位： | 佳木斯大学附属第一医院妇产科; |
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| 摘 要： | 目的:探讨环氧合酶-2(COX-2)和血管内皮生长因子(VEGF)在子宫内膜异位症(EMs)组织中的表达,以及COX-2及VEGF对血管形成的影响。为子宫内膜异位症的发病机制、治疗以及预防的研究提供理论依据。方法:应用链霉素抗生物素蛋白-过氧化物酶连接免疫组织化学法对32例子宫内膜异位症患者组织中COX-2和VEGF的表达进行检测。结果:环氧合酶-2在正常子宫内膜(54.50%)、子宫内膜异位症在位内膜(62.50%)及子宫内膜异位症异位组织中(81.25%)的表达阳性率逐渐升高,差异有显著性意义(P<0.01);正常内膜及子宫内膜异位症在位内膜中环氧合酶-2表达受月经周期影响,分泌期的阳性表达率(60.00%,66.67%)高于增生期(50.00%,57.14%),差异有显著性意义(P<0.05,p<0.01);血管内皮生长因子在正常内膜(51.51%)、子宫内膜异位症在位内膜(59.38%)及子宫内膜异位症异位组织中(93.75%)的表达阳性率逐渐升高,差异有显著性意义(P<0.01)。正常内膜及子宫内膜异位症在位内膜中血管内皮生长因子表达受月经周期影响,分泌期的阳性表达率(53.33%,72.22%)高...
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| 关 键 词： | 子宫内膜异位症 环氧合酶-2 血管内皮生长因子 免疫组织化学 |
Cyclooxygenase-2 And Angiogenesis In Endometriosis-Related Research |
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| Ping Xiaona,Du Jiaqiu. Cyclooxygenase-2 And Angiogenesis In Endometriosis-Related Research[J]. Friend of Science Amateurs, 2011, 0(17) |
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| Authors: | Ping Xiaona Du Jiaqiu |
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| Affiliation: | Ping Xiaona,Du Jiaqiu |
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| Abstract: | Objective:To investigate cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF)in endometriosis(EMs)tissues,and COX-2 and VEGF on angiogenesis.Of endometriosis in the pathogenesis,treatment and prevention studies provide a theoretical basis.Methods:streptomycin avidin-peroxidase immunohistochemistry in 32 cases of endometrial tissue in endometriosis patients with COX-2 and VEGF expression were detected.Results:COX-2 in normal endometrium(54.50%),endometriosis eutopic endometrium(62.50%)and ect... |
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| Keywords: | endometriosis cyclooxygenase-2 vascular endothelial growth factor immunohistochemistry |
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