| 过敏性紫癜的免疫生物学研究进展 |
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| 引用本文： | 谢海棠,张剑白.过敏性紫癜的免疫生物学研究进展[J].内蒙古民族大学学报(自然科学版),2009,24(4):453-456. |
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| 作者姓名： | 谢海棠 张剑白 |
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| 作者单位： | 1. 内蒙古民族大学附属医院,内蒙古,通辽,028000
2. 哈尔滨医科大学第一附属医院,黑龙江,哈尔滨,150001 |
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| 摘 要： | 过敏性紫癜（HSP）是一种常见但病因不明的系统性小血管炎,多发于儿童.存在着体液免疫和细胞免疫异常,可出现T细胞功能紊乱和多种促炎因子异常,其免疫复合物可激活补体进一步发挥作用,IgA的作用也不容忽视.HSP并非单一因素作用的结果,而是免疫反应异常、遗传因素、疾病诱因等多方面综合作用的结果.本文对该病相关的病原体,以IgA为主的免疫调节,以及患儿的免疫遗传学相关方面进行了综述,并提出了一个HSP发生发展的假设模型,并认为它可能是血管炎类疾病共有的模式.
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| 关 键 词： | 过敏性紫癜 免疫学异常 血管炎 |
Progress in Research on Immunobiology of Henoch-Schonlein Purpura |
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| XIE Hai-tang,ZHANG Jian-bai.Progress in Research on Immunobiology of Henoch-Schonlein Purpura[J].Journal of Inner Mongolia University for the Nationalities(Natural Sciences),2009,24(4):453-456. |
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| Authors: | XIE Hai-tang ZHANG Jian-bai |
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| Institution: | XIE Hai-tang ,ZHANG Jian-bai(1.Affiliated Hospital,Inner Mongolia University for Nationalities,Tongliao 028000,China; 2.The First Affiliated Hospital,Harbin Medical University,Harbin 150001,China) |
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| Abstract: | Henoch-Sch？nlein purpura（HSP） is a systemic small vessel vasculitis.It is common but etiology unknownand mostly occurs in children.The patients exist humoral immunity and cellular immune abnormalities,may appear T-cell dysfunction and a variety of pro-inflammatory factors abnormities.The immune complexes can activate complement to play a further role.The role of IgG either can not be ignored.HSP is not the result of a single factor,but the result of combined effects of multiple factors such as abnormal immune response,genetic factors,disease inducement etc.This paper reviews the disease-related pathogens,immunoregulation,as well as immunogenetics aspect of children and puts forward a hypothetical model of the occurrence and development of HSP,and thinks it may be the common model of vasculitis diseases. |
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| Keywords: | HSP Abnormal immune Vasculitis |
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