The action of muscimol on neurones of the substantia nigra of the rat

Summary Muscimol and GABA applied microintophoretically onto nigral neurones reduce the discharge rate of most of these cells. Bicuculline reversibly antagonizes the action of muscimol. I.p. applied muscimol reduces the firing rate of about half of the nigral cells tested.The valuable assistance of Mrs Alice Fonjallaz is warmly acknowledged.