Adenosine promoted accumulation of adenosine 3′,5′-monophosphate in rabbit vagus nerve |
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| Authors: | P. Roch A. Salamin |
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| Affiliation: | (1) Department de Pharmacologie, 20, Ecole de Médecine, CH-1211 Genève 4, Switzerland |
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| Abstract: | Summary Desheathed rabbit vagus nerve has been found to form cyclic AMP when incubated with adenosine. This accumulation of cyclic AMP is inhibited by theophylline but not by antiadrenergic agents, anticholinergic agents or local anaesthetics. Depolarizing media are not able to promote cyclic AMP accumulation in this preparation.Acknowledgment. We gratefully acknowledge Mr.G. Jones for valuable discussion, MrsM. Moosmayer and Mr.S. Ferrara for expert technical assistance and Swiss National Science Foundation for grant support (Nr. 3.478.0.75). |
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