Reduction of aflatoxin B1 with zinc borohydride: An efficient preparation of aflatoxicol |
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Authors: | M. -T. Stephen Hsia F. S. Chu |
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Affiliation: | (1) Food Research Institute and Department of Food Microbiology and Toxicology, University of Wisconsin, 53706 Madison, Wisconsin, USA |
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Abstract: | Summary A simple and mild reduction of aflatoxin B1, involving treatment of aflatoxin B1 with ethereal zinc borohydride to give 57–65% yield of diastereomeric aflatoxicols, is described.This work was supported by the College of Agricultural and Life Sciences, the University of Wisconsin, Madison, and by Public Health Service Research, grant No. CA 15064, from the National Cancer Institute, and by funds from contributions of food industries to the Food Research Institute. We are grateful to Professor Dennis Hsieh for a gift of natural aflatoxicol, to Mr William Harder for technical assistance throughout this investigation, and to Mr Gary Girdaukas for taking mass spectra. |
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