| 3种黄酮类小分子与牛血清白蛋白间相互作用及其构效关系的研究 |
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| 引用本文： | 陶慧林,寿红娟,朱仕毅.3种黄酮类小分子与牛血清白蛋白间相互作用及其构效关系的研究[J].广西科学院学报,2010,26(3):338-342. |
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| 作者姓名： | 陶慧林 寿红娟 朱仕毅 |
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| 作者单位： | 桂林理工大学化学与生物工程学院,广西桂林,541004 |
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| 摘 要： | 解析3种黄酮类小分子桑色素(MOR)、槲皮素(QUE)、芦丁(RUT)与牛血清白蛋白(BSA)相互作用后的紫外-可见光谱和荧光猝灭光谱,研究在同一实验条件下黄酮类小分子与BSA的相互作用及其构效关系。结果显示,黄酮母核B环上的羟基处于相邻位置时,比处于其他位置时表现出的BSA猝灭作用和结合作用更强,而有较大取代基团存在时,由于位阻较大,黄酮类小分子与BSA间的猝灭作用及结合作用则明显变弱。
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| 关 键 词： | 黄酮 牛血清蛋白 相互作用 构效关系 |
| 收稿时间： | 2010/6/20 0:00:00 |
Study of Interaction and Structure-Activity Relation-ships between Three Flavonoids and BSA |
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| TAO Hui-lin,SHOU Hong-juan and ZHU Shi-yi.Study of Interaction and Structure-Activity Relation-ships between Three Flavonoids and BSA[J].Journal of Guangxi Academy of Sciences,2010,26(3):338-342. |
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| Authors: | TAO Hui-lin SHOU Hong-juan and ZHU Shi-yi |
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| Institution: | (Department of Chemistry and Biological Engineering,Guilin University of Technology,Guilin,Guangxi,541004,China) |
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| Abstract: | The structure-activity relationship and interaction between three flavonoids including Morin（MOR）,Quercetin（QUE） and Rutin（RUT） and BSA were observed by UV-visible spectra and fluorescence quenching spectra.The results showed that the quenching and binding effect between flavonoids and BSA were strong when the.hydroxyl group was in the adjacent position of B benzene ring of nucleus.However,the quenching and binding effect between flavonoids and BSA decreased when a large group existed,which is due to the steric hindrances. |
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| Keywords: | flavonoids bovine serum albumin interaction structure-activity relationships |
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