New bone induction by demineralized bone matrix in immunosuppressed rats |
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| Authors: | A Maru?i? I Diki? S Vuki?evi? M Maru?i? |
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| Institution: | (1) Department of Anatomy, University of Zagreb,  alata 11, P.O. Box 916, 41000 Zagreb, Croatia;(2) Department of Physiology and Immunology, School of Medicine, University of Zagreb, alata 11, P.O. Box 916, 41000 Zagreb, Croatia |
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| Abstract: | Subcutaneous implantation of demineralized bone matrix (DBM) initiates a sequence of developmental events which culminate in endochondral bone formation. To test the effects of T-cell deficiency on new bone formation, the morphology of DBM-induced bone was examined in rats thymectomized at three weeks of age and in thymectomized or nonthymectomized rats lethally irradiated and reconstituted with syngeneic bone marrow. At 24 days after implantation, bone induction in control rats was appropriate for their age, while thymectomized-irradiated-reconstituted rats and thymectomized rats had significantly more new bone and larger bone marrow space than the controls. In non-thymectomized, irradiated and reconstituted rats, bone induction occurred in only 25% of the animals, compared to 95% in other groups. |
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| Keywords: | Bone matrix osteoinduction thymectomy irradiation bone marrow reconstitution immunosuppression |
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