| 7-芳基取代吡唑并[1,5-a]嘧啶衍生物的合成与表征 |
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| 引用本文： | 王为玲.7-芳基取代吡唑并[1,5-a]嘧啶衍生物的合成与表征[J].长春工程学院学报(自然科学版),2010,11(1):117-120. |
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| 作者姓名： | 王为玲 |
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| 作者单位： | 长春工程学院,理学院,长春,130012 |
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| 摘 要： | 通过芳基烯胺酮与5-氨基-1H-吡唑的关环反应合成了一系列7-芳基吡唑并1,5-a]嘧啶衍生物。首先芳酮(8)与N,N-二甲基甲酰胺二甲基缩醛缩合得到芳基烯胺酮(9),不经纯化,直接在乙酸回流条件下与5-氨基-1H-吡唑反应合成了7-芳基吡唑并1,5-a]嘧啶,产率为45%~86%。目标化合物结构经1H-NMR和IR进行了表征。该方法具有原料易得,操作简便等特点。
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| 关 键 词： | 合成 吡唑并[1 5-a]嘧啶 芳酮 |
The synthesis and properties of 7-Aryl substituted pyrazolo [1,5-a] pyrimidines |
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| WANG Wei-ling.The synthesis and properties of 7-Aryl substituted pyrazolo [1,5-a] pyrimidines[J].Journal of Changchun Institute of Technology(Natural Science Edition),2010,11(1):117-120. |
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| Authors: | WANG Wei-ling |
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| Institution: | Faculty of Sciences;Changchun Institute ofTechnology;Changchun 130012;China |
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| Abstract: | Seven new 7-aryl substituted pyrazolo 1,5-a] pyrimidine derivatives are synthesized by the reaction of aryl enaminones with 5-amino-1H-pyrazoles in good yields.First,aryl ketone 8 condenses with DMF.DME to give aryl enaminones 9.Then the intermediate 9 reactes with 5-amino-1H-pyrroles in refluxing glacial acetic acid and the desired 7-aryl substituted pyrazolo 1,5-a] pyrimidines are obtained in 45%~86% yields.Their structures are determined by 1H-NMR and IR.The method is high efficiency and simple operati... |
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| Keywords: | synthesis pyrrolo [1 5-a] pyrimidines aryl ketones |
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