Insulin stimulation of glucose and amino acid transport in mouse fibroblasts with elevated membrane microviscosity |
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| Authors: | I. Yuli S. Incerpi P. Luly M. Shinitzky |
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| Affiliation: | (1) Department of Membrane Research, The Weizmann Institute of Science, Rehovot, (Israel);(2) Present address: Department of Physiology, University of Rome, Rome, (Italy) |
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| Abstract: | Summary Basal and insulin-stimulated transport of 2-deoxy glucose and of  -aminoisobutyric acid in mouse 3T3 fibroblasts were modulated by increasing the lipid microviscosity of the cell plasma membrane. The kinetics indicate that the insulin effect is induced either by recruitment of new transport carriers or by reduction of the translocation activation energy.This investigation was supported by grant No.5-R01-CA-27471-02, awarded by the National Cancer Institute, Department of Health, Education and Welfare. |
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