Presence of oncornavirus-like particles in the P388 murine leukemic cell line |
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| Authors: | J. M. Schmidt G. R. Pettit |
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| Affiliation: | (1) Cancer Research Institute and Department of Chemistry, Arizona State University, 85281 Tempe, Arizona;(2) Present address: Department of Botany and Microbiology, Arizona State University, 85281 Tempe, Arizona |
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| Abstract: | Summary A culture of P388 murine lymphoblastoid cells has been shown to contain type C oncornavirus-like particles budding at the plasma membrane. Occasionally intracytoplasmic type A and immature type B particles were also observed by electron microscope techniques. The discovery of oncornavirus-like particles in the P388 cell line increases the utility of this neoplastic system for detecting potential antineoplastic agents.Supported by Contract NO1-CM-67048 from the Division of Cancer Treatment (DCT), National Cancer Institute (NCI), National Institutes of Health, Department of Health, Education, and Welfare. The fannie E. Rippel Foundation, Talley Industries, and the Phoenix Coca Cola Bottling Co. We are also grateful to Miss Linda M. Lange for technical assistance. |
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