Induction of rotational behaviour by intranigral baclofen suggests possible GABA-agonist activity |
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| Authors: | J L Waddington |
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| Institution: | (1) Division of Psychiatry, MRC Clinical Research Centre, HA1 3UJ Harrow, Middleses, England |
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| Abstract: | Summary In rats, unilateral injections of the GABA-derivative baclofen into the zona reticulata of the substantia nigra produced a contralateral rotation that was translated to ipsilateral rotation under the influence of amphetamine. These results mimic those following unilateral elevation of GABA levels in the substantia nigra and suggest that baclofen may have some GABA agonist activity following intracerebral injection.Baclofen was a generous gift of Ciba-Geigy Ltd.J. L. W. is a Medical Research Council Scholar. |
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