Role of 5-hydroxytryptamine in prostaglandin E1-induced potentiation of hexobarbitone hypnosis in albino rats |
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| Authors: | S K Bhatacharya S N Mukhopadhyay P K Debnath A K Sanyal |
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| Institution: | (1) Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, 221005 Varanasi, (India) |
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| Abstract: | Summary PGE1 potentiated, while diclofenac, a prostaglandin synthesis inhibitor, antagonized hexobarbitone hypnosis in rats. PGE1-induced potentiation of hexobarbitone sleep was inhibited by a 5HT synthesis inhibitor and by a 5HT receptor blocker, suggesting that this potentiation is 5HT mediated.Acknowledgment. The gift of the following drugs are gratefully acknowledged: PGE1 (Dr.J. E. Pike, Upjohn), diclofenac (Ciba-Geigy), methysergide (Sandoz) and hexobarbitone (Bayer). |
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