神经元兴奋性群体峰电位信号的Renyi信息表达

应用时频分布级数分析方法，提取了单次诱发群体峰电位(PS)信号的Renyi信息，并用以表征神经元的兴奋性变化．采用液压打击大鼠脑损伤模型和细胞外记录技术，记录了离体海马脑片CA1区锥体神经元PS，发现损伤侧和非损伤侧PS的Renyi信息参数值差异显著，进而分析了神经元灌流大黄酸后损伤侧PS的Renyi信息参数值的变化，研究大黄酸对神经元的超兴奋性和突触传递的作用．研究结果表明，颅脑损伤可造成海马CA1区锥体神经元的迟发性过度兴奋，大黄酸对神经元的过度兴奋有抑制作用，Renyi信息可作为反映神经元兴奋性变化的一个特征参数．

Expression of Neuronal Excitability in Renyi Information of Population Spike

With discrete time frequency distribution series (DTFDS), the Renyi information (RI) was extracted from single trial population spike(PS) to represent the change of neuronal excitability. By adopting fluid percussion brain injury model and extracellular recording technique, PS signals were collected from rat hippocampal CA1 pyramidal neurons in vitro. By analyzing the PS signals, it is found that a remarkable difference in the RI value of the PS appears on the ipsilateral (impact side) and contralateral hippocampal CA1 areas. Then Rhein is adopted to investigate how it affects the neuronal hyperexcitability and synaptic transmission. The result indicates that traumatic head injury may lead to delayed hyperexcitability of hippocampal CA1 pyramidal neurons and that Rhein can depress the neuronal hyperexcitablity. RI may be regarded as a reference index to express the neuronal excitability.