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Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma |
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| Authors: | Li Meng Zhao Hong Zhang Xiaosong Wood Laura D Anders Robert A Choti Michael A Pawlik Timothy M Daniel Hubert D Kannangai Rajesh Offerhaus G Johan A Velculescu Victor E Wang Linfang Zhou Shibin Vogelstein Bert Hruban Ralph H Papadopoulos Nick Cai Jianqiang Torbenson Michael S Kinzler Kenneth W |
| Affiliation: | Ludwig Center for Cancer Genetics and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. |
| Abstract: | Through exomic sequencing of ten hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCC) and subsequent evaluation of additional affected individuals, we discovered novel inactivating mutations of ARID2 in four major subtypes of HCC (HCV-associated HCC, hepatitis B virus (HBV)-associated HCC, alcohol-associated HCC and HCC with no known etiology). Notably, 18.2% of individuals with HCV-associated HCC in the United States and Europe harbored ARID2 inactivation mutations, suggesting that ARID2 is a tumor suppressor gene that is relatively commonly mutated in this tumor subtype. |
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