Perspectives for vascular genomics |
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Authors: | Rubin E M Tall A |
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Institution: | Lawrence Berkeley National Laboratory, Genome Sciences Department, Berkeley, California 94720, USA. emrubin@lbl.gov |
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Abstract: | Diseases of the vascular system result from a complex mixture of genetic and environmental factors. Data sets, technologies and strategies emanating from the human genome programme have been applied to the analysis of both rare single-gene and common multigenic vascular disorders. Genomic approaches including inter- and intraspecies sequence comparisons, genotyping with dense marker sets spanning the genome, large-scale mutagenesis screens of model organisms, and genome-wide expression profiling have all begun to contribute to the identification of new genes and mechanisms that are central to cardiovascular disease processes. |
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