| 壳聚糖-海藻酸盐复合物的表征及其吸湿性和崩解性研究 |
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| 引用本文： | 陆轶业,刘黎,张亚琼,郭圣荣. 壳聚糖-海藻酸盐复合物的表征及其吸湿性和崩解性研究[J]. 上海交通大学学报, 2007, 41(10): 1683-1686 |
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| 作者姓名： | 陆轶业 刘黎 张亚琼 郭圣荣 |
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| 作者单位： | 上海交通大学,药学院,上海,200240;上海交通大学,药学院,上海,200240;上海交通大学,药学院,上海,200240;上海交通大学,药学院,上海,200240 |
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| 基金项目： | 上海交通大学校科研和教改项目;上海市科委资助项目 |
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| 摘 要： | 壳聚糖和海藻酸钠在水溶液中能以静电自组装形成聚电解质复合物.利用红外光谱和元素分析表征复合物结构,考察复合物的结晶性、吸湿性及压片后的崩解性.结果表明,壳聚糖-海藻酸盐复合物呈无定型态,其吸湿性明显高于壳聚糖和海藻酸钠本身,特别是在pH值为5.0条件下得到的复合物吸湿性较大.崩解性实验表明,复合物具有相当好的崩解性能.
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| 关 键 词： | 壳聚糖 海藻酸钠 复合物 吸湿性 崩解性 |
| 文章编号： | 1006-2467（2007）10-1683-04 |
| 修稿时间： | 2006-11-06 |
The Characterization, Moisture-absorption Abilities and Disintegration of the Complexes of Chitosan-Alginate |
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| LU Yi-ye,LIU Li,ZHANG Ya-qiong,GUO Sheng-rong. The Characterization, Moisture-absorption Abilities and Disintegration of the Complexes of Chitosan-Alginate[J]. Journal of Shanghai Jiaotong University, 2007, 41(10): 1683-1686 |
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| Authors: | LU Yi-ye LIU Li ZHANG Ya-qiong GUO Sheng-rong |
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| Affiliation: | School of Pharmacy, Shanghai Jiaotong Univ. , Shanghai 200240, China |
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| Abstract: | Chitosan and alginate can form polyelectrolyte complexes in water via electrostatic interaction.The complexes were characterized by FTIR and element analysis,and their crystallization,moisture-absorption and disintegration were also investigated.The results show that chitosan-alginate complexes present amorphous state,and their moisture-absorption abilities are better than the original chitosan and alginate.The complexes have great moisture-absorption abilities when prepared from the solution of pH 5.0.The complexes exhibit excellent disintegration effect. |
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| Keywords: | chitosan alginate complex moisture-absorption ability disintegration |
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