Fluorescence microscopical study of 5-hydroxytryptamine storage organelles in mepacrine-incubated blood platelets of beige mice (Chediak-Higashi syndrome) |
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| Authors: | H. P. Lorez M. Da Prada |
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| Affiliation: | (1) Department of Pharmaceutical Research, F. Hoffmann-La Roche & Co. Ltd, CH-4002 Basle, Switzerland |
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| Abstract: | Summary The number and fluorescence intensity of fluorescent granules (5-HT storage organelles) of mepacrine-incubated blood platelets of beige mice (Chediak-Higashi syndrome) are decreased compared to those of control mice platelets. This indicates both quantitative and qualitative changes of the 5-HT organelles, namely a reduced number and a reduced storage capacity, respectively. |
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