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| 普萘洛尔在1-萘万古霉素手性柱上的对映体分离 | |
| 引用本文： | 余小燕,黄飞燕,吴双凤,赵守仁,沈报春.普萘洛尔在1-萘万古霉素手性柱上的对映体分离[J].云南民族大学学报(自然科学版),2011,20(2). |
| 作者姓名： | 余小燕 黄飞燕 吴双凤 赵守仁 沈报春 |
| 作者单位： | 1. 昆明医学院,药学院,云南,昆明,650500 2. 云南民族大学,化学与生物技术学院,云南,昆明,650500 3. 云南白药集团研究院,云南,昆明,650118 |
| 基金项目： | 云南省自然科学基金，民族药资源化学国家民委-教育部重点实验室开放基金，昆明医学院2009年大学生创新性实验计划项目 |
| 摘 要： | 在自制的1-萘万古霉素手性色谱柱上对普萘洛尔进行了对映体分离研究.讨论了极性流动相中不同浓度的酸、碱添加剂对普萘洛尔对映体分离的影响,并初步探讨了其手性识别机理.结果表明,自制的1-萘万古霉素手性柱对普萘洛尔对映体具有一定的分离效果,流动相中酸、碱添加荆比例为0.001%:0.001%(v/v)时,选择因子达到1.16. |
| 关 键 词： | 对映体分离 普萘洛尔 极性流动相 手性识别机理 1-萘万古霉素手性固定相 |
Enantioseparation of Propranolol on the 1-Naphthalene Vancomycin Chiral Stationary Phase |
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| YU Xiao-yan,HUANG Fei-yan,WU Shuang-feng,ZHAO Shou-ren,SHEN Bao-chun.Enantioseparation of Propranolol on the 1-Naphthalene Vancomycin Chiral Stationary Phase[J].Journal of Yunnan Nationalities University:Natural Sciences Edition,2011,20(2). | |
| Authors: | YU Xiao-yan HUANG Fei-yan WU Shuang-feng ZHAO Shou-ren SHEN Bao-chun |
| Institution: | YU Xiao-yan1,HUANG Fei-yan2,WU Shuang-feng1ZHAO Shou-ren3,SHEN Bao-chun1(1.School of Pharmaceutical Science,Kunming Medical University,Kunming 650500,China,2.School of Chemistry and Biotechnology,Yunnan University of Nationalities,3.Research Institute of Yunnan Baiyao Group,Kunming 650118,China) |
| Abstract: | On the self-made 1-naphthalene vancomycin chiral stationary phase,the enantioseparation of propranolol was studied by using the polar mobile phase.The influence of acid and alkali additive in the polar mobile phase was investigated.The chiral recognition mechanism was also discussed.The result shows that the isomers of propranolol can be separated on the self-made 1-napthalene vancomycin chiral stationary phase in the polar mobile phase.The separation factor was 1.16 while using the acid and alkali additive... |
| Keywords: | enantioseparation propranolol polar mobile phase chiral recognition mechanism 1-Naphthalene vancomycin chiral stationary phase |
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