Structural relationships between the endogenous volatile urinary metabolites of experimentally diabetic rats and certain neurotoxins |
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| Authors: | G Rhodes Mary L Holland D Wiesler M Novotny S A Moore R G Peterson D L Felten |
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| Institution: | (1) Department of Chemistry, Indiana University, 47405 Bloomington, Indiana, USA;(2) Department of Anatomy, Indiana University School of Medicine, 46202 Indianapolis, Indiana, USA |
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| Abstract: | Summary High resolution glass capillary gas chromatography and GC/MS were utilized to examine qualitative and quantitative variations from normal of urinary volatile metabolites of long-term alloxan and streptozotocin diabetic rats. Volatile metabolites were structurally compared with known neurotoxins to examine any possible relationship between these metabolites and the development of the diabetic polyneuropathy.Acknowledgment. This research was supported by grant No. 24349 from the National Institute of General Medical Sciences, U.S. Public Health Service. |
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