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| 血府逐瘀汤对动脉粥样硬化大鼠血脂及血管活性物质的影响 | |
| 引用本文： | 耿兆辉,寿保栋,刘辉,杨永滨,任今今.血府逐瘀汤对动脉粥样硬化大鼠血脂及血管活性物质的影响[J].河北大学学报(自然科学版),2011,31(3):304-308. |
| 作者姓名： | 耿兆辉 寿保栋 刘辉 杨永滨 任今今 |
| 作者单位： | 1. 河北大学教务处,河北保定,071002 2. 河北医科大学基础医学院,河北,石家庄,050017 3. 河北大学公共卫生学院,河北,保定,071000 4. 河北大学,基础医学院,河北,保定,071000 |
| 基金项目： | 河北省卫生厅医学科学研究重点课题，河北省科技支撑计划项目，河北省中医药管理局科学技术研究课题 |
| 摘 要： | 通过观察血府逐瘀汤对动脉粥样硬化(atherosclerosis,AS)大鼠血脂及血管内皮活性因子的影响,探讨血府逐瘀汤抗动脉粥样硬化的机制.将40只SD大鼠随机分为对照组、模型组、治疗组(血脂康组、血府逐瘀汤高剂量组、血府逐瘀汤低剂量组).对照组给予正常饮食;模型组给予高脂饮食;治疗组在高脂饮食基础上分别给予血脂康,... |
| 关 键 词： | 血府逐瘀汤 动脉粥样硬化 内皮素 血管紧张素Ⅱ |
Effect of Xuefu Zhuyu Decoction on the Expression of Blood-lipid and Vasoactive Substances in the Rats with Atherosclerosis |
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| GENG Zhao-hui,SHOU Bao-dong,LIU Hui,YANG Yong-bin,REN Jin-jin.Effect of Xuefu Zhuyu Decoction on the Expression of Blood-lipid and Vasoactive Substances in the Rats with Atherosclerosis[J].Journal of Hebei University (Natural Science Edition),2011,31(3):304-308. | |
| Authors: | GENG Zhao-hui SHOU Bao-dong LIU Hui YANG Yong-bin REN Jin-jin |
| Institution: | 1.Office of Academic Affairs,Hebei University,Baoding 071002,China;2.College of Basic Medical Scicnce,Hebei Medical University,Shijiazhuang 050017,China;3.School of Public Health,Hebei University,Baoding 071000,China;4.College of Basic Medical Science,Hebei University,Baoding 071000,China) |
| Abstract: | To investigate the effect of Xuefu Zhuyu decoction on the expression of blood-lipid and vasoactive substances in the rats with atherosclerosis.Forty SD rats were randomly divided into control group,model group and treatment group(Xuezhikang group,Xuefu Zhuyu high-dose group,and Xuefu Zhuyu low dose group).The control group was fed with normal diet,model group a high-fat diet,treatment groups the high fat diet mixed with Xuezhikang,High dose and low dose Xuefu Zhuyu decoction respectively.The morphological changes of atheromatous plaque were observed 12 weeks later.The blood level of total cholesterol,triglyceride,low density lipoprotein,high-density lipoprotein,and endothelin(ET) angiotensin Ⅱ(Ang Ⅱ) were tested at the same time.Compared with the model group,all the treatment groups could reduce the serum levels of total cholesterol,triglycerides,low density lipoprotein,ET and Ang Ⅱ(P<0.05),and increase high-density lipoprotein(P<0.05).It was found that Xuefu Zhuyu decoction could effectively regulate the serum level of lipidemia of AS rats,reduce the activity of vascular endothelial factors,and protecting the endothelium,and then prevent and cure atherosclerosis effectively. |
| Keywords: | Xuefu Zhuyu decoction atherosclerosis endothelins angiotensin |
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