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| Reconstruction of the most recent common ancestor sequences of SARS-Cov S gene and detection of adaptive evolution in the spike protein | |
| 作者姓名： | ZHANGYuan ZHENGNan HAOPei ZHONGYang |
| 作者单位： | [1]LaboratoryofSystematicandEvolutionaryBotany,InstituteofBotany.ChineseAcademyofSciences,Beijing100093,China [2]CollegeofLifeSciences,BeijingNormalUniversity,Beijing100875.China [3]BioinformationCenter,ShanghaiInstitutesforBiologicalSciences.ChineseAcademyofSciences,Shanghai200031,China [4]SchoolofLifeSciences,FudanUniversity,Shanghai200433,China |
| 摘 要： | The genome organization and expression strategy of severe acute respiratory syndrome coronavirus (SARS-CoV) have been described extensively. As a structural glycoprotein on the virion surface, the spike protein is responsible for binding to host cellular receptors and for the fusion between the viral envelope and the cellular membrane. It also induces neutralizing antibodies in |
| 关 键 词： | SARS冠状病毒 自适应进化 基因表达 糖蛋白 分子免疫学 波峰病毒 |
| 收稿时间： | 2004-04-05 |
| 修稿时间： | 2004-05-19 |
Reconstruction of the most recent common ancestor sequences of SARS-Cov S gene and detection of adaptive evolution in the spike protein |
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| ZHANGYuan ZHENGNan HAOPei ZHONGYang.Reconstruction of the most recent common ancestor sequences of SARS-Cov S gene and detection of adaptive evolution in the spike protein[J].Chinese Science Bulletin,2004,49(12):1311-1313. | |
| Authors: | Zhang Yuan Zheng Nan Hao Pei Zhong Yang |
| Institution: | 1. Laboratory of Systematic and Evolutionary Botany, Institute of Botany, Chinese Academy of Sciences, 100093, Beijing, China 2. College of Life Sciences, Beijing Normal University, 100875, Beijing, China 3. Institute of Viral Disease Control and Prevention, Chinese CDC, 100052, Beijing, China 4. Bioinformation Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 200031, Shanghai, China 5. Shanghai Center for Bioinformation Technology, 200235, Shanghai, China 6. School of Life Sciences, Fudan University, 200433, Shanghai, China |
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