| 慢性噪音暴露诱发小鼠低焦虑样行为及其分子机制的研究 |
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| 引用本文： | 王丽丽,孟博,顾怡然,李梦丹,高虹.慢性噪音暴露诱发小鼠低焦虑样行为及其分子机制的研究[J].复旦学报(自然科学版),2011(3):352-359. |
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| 作者姓名： | 王丽丽 孟博 顾怡然 李梦丹 高虹 |
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| 作者单位： | 华东师范大学教育部及上海市脑功能基因组学重点实验室; |
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| 基金项目： | 华东师范大学科研创新基金资助项目 |
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| 摘 要： | 噪音日益严重地影响着人类的健康，为了探讨慢性噪音对小鼠情绪和注意力的影响及其分子机制.分别给予6周龄雄性小鼠以噪音刺激(75 dB，8 h/d)，连续30 d后检测小鼠与情绪和注意力相关的行为表现.结果发现，噪音组小鼠在开场实验中心区域运动距离的百分比升高，在明暗箱实验中表现为在明箱中运动时间增多以及在强迫游泳实验中静...
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| 关 键 词： | 噪音暴露 低焦虑 GAD65 GABAA受体 NMDA受体 |
Chronic Noise Exposure Caused Low-Anxiety in Mice and Its Underlying Molecular Mechanisms |
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| WANG Li-li,MENG Bo,GU Yi-ran,LI Meng-dan,GAO Hong.Chronic Noise Exposure Caused Low-Anxiety in Mice and Its Underlying Molecular Mechanisms[J].Journal of Fudan University(Natural Science),2011(3):352-359. |
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| Authors: | WANG Li-li MENG Bo GU Yi-ran LI Meng-dan GAO Hong |
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| Institution: | WANG Li-li,MENG Bo,GU Yi-ran,LI Meng-dan,GAO Hong(Key Laboratory of Brain Functional Genomics,MOE & STCSM,East China Normal University,Shanghai 200062,China) |
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| Abstract: | Noise is recognized as a serious health problem.To understand the effects of chronic noise exposure on emotion and attention in mice and its underlying molecular mechanisms,the C57BL/6 male mice(postnatal 6 weeks) were exposed to noise(75dB,8 h daily) and environment noise(control) separately for consecutive 30 days,then their behaviors related to emotion and attention were analyzed.The results showed that the noise group explored the center portion of the field(as center locomotor) more than control group ... |
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| Keywords: | noise exposure low-anxiety GAD65 GABAAreceptor NMDA receptor |
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