| 多功能磁性纳米药物载体的制备及表征 |
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| 引用本文： | 尚 乐,周庆翰.多功能磁性纳米药物载体的制备及表征[J].西南民族大学学报(自然科学版),2016,42(5):531-537. |
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| 作者姓名： | 尚 乐 周庆翰 |
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| 作者单位： | 西南民族大学化学与环境保护工程学院,西南民族大学化学与环境保护工程学院 |
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| 基金项目： | 自然科学基金青年项目（21404086） |
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| 摘 要： | 以AIBN为引发剂,以N,N'-双(丙烯酰)胱胺(BACy)为交联剂,与多巴胺丙烯酰胺(DMA)和聚乙二醇单甲醚甲基丙烯酸酯(PEGMA)发生共聚,同时加入Fe_3O_4磁性纳米粒子,制备得到纳米胶束.通过核磁(~1H-NMR),红外(FTIR),动态光散射(DLS)和透射电镜(TEM)等一系列手段对聚合物胶束的结构和形貌进行了表征,初步证明了制备的胶束具有还原响应性和良好的稳定性.
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| 关 键 词： | 磁性纳米粒子 BACy 胶束 |
| 收稿时间： | 2016/6/6 0:00:00 |
| 修稿时间： | 2016/8/31 0:00:00 |
Synthesis and characterization of multifunctional magnetic nano drug carrier |
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| shangle and zhouqinghan.Synthesis and characterization of multifunctional magnetic nano drug carrier[J].Journal of Southwest University for Nationalities(Natural Science Edition),2016,42(5):531-537. |
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| Authors: | shangle and zhouqinghan |
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| Institution: | College of Chemistry&Environment Protection Engineering,Southwest University for Nationalities,College of Chemistry&Environment Protection Engineering,Southwest University for Nationalities |
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| Abstract: | A novel disulfide bonded cross-linked copolymer was synthesized using AIBN as initiator, N,N-bis(acryloyl) cystamine(BACy) as crosslinker,and the monomers also contain dopamine methacrylamide(DMA), polyethylene glycol ether methacrylate (PEGMA) and Fe3O4 magnetic nanoparticles, 1H-NMR,FTIR, DLS and TEM were utilized to investigate the chemical structure and micelle morphology.The results indicated that the micelles were stable and degraded in reducing agent. |
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| Keywords: | magnetic nanoparticles BACy micelle |
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