Somatostatin immunoneutralization overcomes the inhibitory effects of quipazine and pargyline on growth hormone secretion in domestic fowl |
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Authors: | S Harvey T R Hall |
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Institution: | (1) Department of Physiology, University of Alberta, T6G 2H7 Edmonton, Alberta, Canada;(2) Biovet Unit, Ciba Geigy, CH-1566 Saint Aubin, (Switzerland) |
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Abstract: | Summary The inhibitory effects of pargyline and quipazine on chicken growth hormone secretion were overcome by passive immunoneutralization of endogenous somatostatin (SRIF)-14 or SRIF-28(1–14)-like immunoreactivity. Administration of the specific antisera to control birds pretreated with 0.9% NaCl elevated the basal plasma GH concentrations. These results suggest that peptides with SRIF-14 or SRIF-28(1–14)-like immunoreactivity tonically inhibit GH secretion and are at least partially responsible for the inhibitory effects of pargyline and quipazine on GH release in immature domestic fowl. |
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Keywords: | Somatostatin growth hormone serotonin |
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