Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with Alzheimer's disease. |
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| Authors: | T Aoyagi T Wada M Nagai F Kojima S Harada T Takeuchi H Takahashi K Hirokawa T Tsumita |
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| Affiliation: | Institute of Microbial Chemistry, Tokyo, Japan. |
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| Abstract: | We examined the changes in the intracerebral activities, at the time of postmortem autopsy, in patients with Alzheimer's disease. When compared with the control group, the activity of kallikrein-like enzyme was significantly decreased, while prolyl endopeptidase activity increased, in the patients group. Aprotinin inhibited 50% of the activity of the former enzyme at 2 x 10(-7) M. Taken together with the results of a multivariate study, the above findings may indicate that intracerebral kallikrein deficiency plays an important role in the pathogenesis of Alzheimer's disease. |
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