| 合成藜芦醛实验的优化与实践 |
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| 引用本文： | 尹红梅,金 辉,齐庆蓉,等. 合成藜芦醛实验的优化与实践[J]. 实验科学与技术, 2014, 0(2): 16-18,25 |
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| 作者姓名： | 尹红梅 金 辉 齐庆蓉 等 |
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| 作者单位： | [1]四川大学 华西药学院,成都610041 [2]四川大学实验室及设备管理处,成都610041 |
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| 基金项目： | 四川大学实验技术项目（2013-132）;中华医学会医学教育分会、中国高等教育学会医学教育专业委员会2012年度医学教育研究项目（2012-FF-122）;2013年四川大学新世纪高等教育教学改革工程项目（SCUY158）. |
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| 摘 要： | 药物化学实验教学中合成藜芦醛的实验效果不理想,拟对其进行优化。从反应机理入手,通过对投料方式、反应温度、溶液的酸碱性、操作的可控性、安全性等多方面分析或预试,提出新实验方案并付诸教学实践。结果表明:实验优化后,既达到节约、高效的目的,又符合绿色、环保的思想,有利于减轻师生教与学的负担,使学生在有限的时间里收获更大、效率更高,从而推动实验教学改革的不断深化。
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| 关 键 词： | 药物化学实验 藜芦醛 实验优化 实验教学改革 |
Optimization and Practice of the Experiment for the Synthesis of Veratraldehyde |
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| YIN Hongmei,JIN Hui,QI Qingrong,HE Guangli,WU Yong,LIAO Yong,LAI Chunxia,ZHANG Yinghong. Optimization and Practice of the Experiment for the Synthesis of Veratraldehyde[J]. Experiment Science & Technology, 2014, 0(2): 16-18,25 |
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| Authors: | YIN Hongmei JIN Hui QI Qingrong HE Guangli WU Yong LIAO Yong LAI Chunxia ZHANG Yinghong |
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| Affiliation: | ( a. West China School of Pharmacy; b. Department of Laboratory and Equipment Management, Sichuan University, Chengdu 610041, China) |
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| Abstract: | In the teaching of medicinal chemistry experiment, the experimental result of veratraldehyde synthesis is not very satisfacto- ry. Starting from the reaction mechanism as well as by analysis and experiment preliminarily based on the feeding mode, reaction tem- perature, pH, controllability and safety, a new experimental scheme has been raised and then has been put into practice. The results showed that it is not only economical and high efficient, but also environmental and green. Meanwhile, it is helpful for reducing the burden of teaching and learning. These may help to improve the reform and development of experimental teaching. |
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| Keywords: | medicinal chemistry experiment synthesis of veratraldehyde experimental optimization reform of experiment teaching |
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