| 用均匀设计优选阿维菌素明胶微球的制备工艺 |
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| 引用本文： | 唐辉,陈文,姚新成,王鲁石,田晨煦.用均匀设计优选阿维菌素明胶微球的制备工艺[J].石河子大学学报,2002,6(1):15-17. |
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| 作者姓名： | 唐辉 陈文 姚新成 王鲁石 田晨煦 |
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| 作者单位： | 石河子大学药学院 石河子832002
(唐辉，陈文，姚新成，王鲁石)，石河子大学药学院 石河子832002(田晨煦) |
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| 基金项目： | 新疆维吾尔自治区科学与技术开发计划 (990 10 10 0 6 ) |
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| 摘 要： | 采用乳化缩聚法，以生物可降解明胶为囊材制备阿维菌素明胶微球，利用从均匀设计法得到的回归方程,优化明胶浓度、乳化剂用量、搅拌速度3个主要因素的水平。结果表明，按优化条件，预测回归值Y＝90．4，实际所得Y＝91．3。说明以均匀设计优选条件制备微球，方法简便，效果良好。
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| 关 键 词： | 阿维菌素 明胶微球 均匀设计 制备工艺 广谱抗寄生虫药 乳化缩聚法 |
| 文章编号： | 1007-7383(2002)01-0015-03 |
| 修稿时间： | 2001年9月24日 |
Uniform Test Design was Applied to Optimize the Formulation and Procedure in the Preparation of AVM-GMS |
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| TANG Hui,CHEN Wen,YAO Xin cheng,WANG Lu shi,TIAN Chen Xu\,.Uniform Test Design was Applied to Optimize the Formulation and Procedure in the Preparation of AVM-GMS[J].Journal of Shihezi University(Natural Science),2002,6(1):15-17. |
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| Authors: | TANG Hui CHEN Wen YAO Xin cheng WANG Lu shi TIAN Chen Xu\ |
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| Abstract: | A kind of optimum procedure was established by uniform test design for preparing the Avermectins Gelatin Microspheres (AVM GMS) by emulsion polymerization to select the formulation and preparation technical process. Under the optimized condition, the theoretical digital Y=90.4 while the practical digital Y=91.3.So according the uniform test design, the process to select suitable conditions of various factors became simple and easy and the result was satisfied. |
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| Keywords: | Avermectins glatin microsphere uniform test design |
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