Misacylation of tRNA in prokaryotes: a re-evaluation |
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| Authors: | A A Stortchevoi |
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| Institution: | (1) School of Medicine, Yale University LH-420, 310 Cedar Street, New Haven, Connecticut 06510, USA |
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| Abstract: | Misacylation of tRNA by a non-cognate amino acid is a natural phenomenon and occurs with a frequency of approximately 1 in
10,000 due to occasional mistakes in aminoacyl transfer RNA (tRNA) synthesis. In a number of prokaryotic organisms, misacylation
of selenocysteinyl tRNA, glutaminyl tRNA and aspartyl tRNAs has particular physiological meaning. Recently, misacylation has
emerged as a powerful tool for studying specific interactions between aa-tRNAs and associated protein factors. The present
review provides an overview of the application of misacylated tRNA in research.
Received 27 April 2005; received after revision 2 November 2005; accepted 5 December 2005 |
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| Keywords: | Misacylation aminoacylation non-cognate trna/amino acid translation prokaryotes suppression |
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