The (Na++K+)-ATPase activity in brain of quaking mice |
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| Authors: | P Mandel V Stefanovic J C Hermetet A Ebel |
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| Institution: | (1) Faculté de Médecine, Centre de Neurochimie du CNRS, and Institut de Chimie Biologique, 11, rue Humann, F-67085 Strasbourg Cedex, (France) |
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| Abstract: | Summary The (Na++K+)- and Mg2+-dependent ATPase distribution in several brain areas has been investigated in Quaking mutant mice characterized by myelin deficiency. A marked decrease of (Na++K+)-ATPase activity has been found in limbic structures, hypothalamus and cerebellum. The Mg2+-dependent activity did not change. A possible involvement of the impairment of the (Na++K+)-ATPase activity in the seizure susceptibility of this mice is discussed.Chargée de Recherche au CNRS. |
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