用两种微核试验观察硒抗重铬酸钾的诱变效应

THE ANTIMUTAGENESIS EFFECT OF SELENIUM ON POTASSIUM DICHROMATE IN TWO MICRONUCLEUS TESTS

The effects 6f selenium and cadmium on micronucleus frequency were observed in a micronucleus test of root tip cells in Vivia Faba and a mouse bone-marrow micronucleus test. The results indicated that selenium and cadmium both have the mutagenic effects. The differences compared with controls were statistically significant at a p value of less than 0.05. 0.01. 0.001, respectively. Both of the chemicals have the clear doseeffect relationship in a certain range of doses or concentrations. The results obtained also show that selenium can apparently decreas the micronucleus frequency induced by pot4ssium dichromate. This demonstrated that selenium was effective in inactivating themutagenicity of potassium dichromate. However, the optimal antimutagenesis effect couldonly be observed in a suitable range and a suitable ratioi of dose / concentration. Sodium selenite has a double character. When it acted together with mutageon, it could inhibit the mutagenic effect and protect the normal gene transference. When it acted alone, it exhibited an unambigUous mutagenic effect.The present results also indicate that it is important to chose the proper dose at the time of using selenium for research and prevention of the mutagenic toxicity.