| 三氧化二砷对原代恶性淋巴瘤细胞的作用 |
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| 引用本文： | 聂林,张洹.三氧化二砷对原代恶性淋巴瘤细胞的作用[J].暨南大学学报,2001,22(2):27-30. |
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| 作者姓名： | 聂林 张洹 |
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| 作者单位： | 暨南大学医学院血液病学研究室, |
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| 基金项目： | 国家自然科学基金!资助项目 (39870 36 1)，广东省自然科学基金!资助项目 (980 710) |
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| 摘 要： | 目的：研究不同浓度的三氧化二砷对原代淋巴瘤细胞的影响，方法：采用台盼蓝拒染法观察细胞的活力，原位末端标记法（TUENL）检测凋亡细胞，流式细胞仪检测细胞的DNA含量，结果：0．5－2．0umol/L三氧化二砷能显著地抑制原代淋巴瘤细胞的活力，并能诱导原代淋巴瘤细胞凋亡，结论：三氧化二砷有可能用于恶性淋巴瘤的治疗。
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| 关 键 词： | 三氧化二砷 淋巴瘤 细胞凋亡 抗肿瘤药物 |
| 文章编号： | 1000-9965(2001)02-0027-04 |
Effect of arsenic trioxide on primary malignant lymphoma cells |
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| NIE Lin,ZHANG Yuan.Effect of arsenic trioxide on primary malignant lymphoma cells[J].Journal of Jinan University(Natural Science & Medicine Edition),2001,22(2):27-30. |
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| Authors: | NIE Lin ZHANG Yuan |
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| Abstract: | Ain:To investigate the effects of a wide range of concentrations of As2O3 on primary lym-phoma cells. Methods: Cell viability were deternined by trypan-blue exclusion. Cell apoptosis situationand cellular DNA contents were deternined by TdT-mediated dUTP Nick-end Labeling (TUNEL) andflow cytometry. Results: It was found that 0.5～2.0 μnol/L As2O3 could significantly reduce viability ofprimary lymphoma cells and induce their apoptosis. Conclusion: It is found that As2O3 could be used totreat malignant lymphoma disease. |
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| Keywords: | arsenic trioxide lymphoma apoptosis |
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