Urogastrone-epidermal growth factor is trophic to the intestinal epithelium of parenterally fed rats |
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| Authors: | R A Goodlad T J G Wilson W Lenton H Gregory K G McCullough N A Wright |
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| Institution: | (1) Department of Histopathology, Royal Postgraduate Medical School, Hammersmith Hospital, Ducane Road, London, (England);(2) Present address: ICI, Alderley Park, Macclesfield;(3) Present address: High Wycombe, Bucks |
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| Abstract: | Summary The weight of the stomach, small intestine and colon and the mucosal crypt cell production rate of these tissues were significantly decreased after 10 days on an isocaloric TPN diet when compared to orally fed controls. Continuous infusion of recombinant beta urogastrone, at a dose below that needed to inhibit gastric acid secretion, largely prevented this decrease in crypt cell production rate and gastrointestinal tissue weights. |
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| Keywords: | Urogastrone epidermal growth factor gastrointestinal tract trophic total parenteral nutrition |
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