The effect of thiazol-4-ylmethoxyamine,a histidine decarboxylase inhibitor,on the development of morphine tolerance and physical dependance in mice |
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| Authors: | Koon-Sea Hui |
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| Institution: | (1) Department of Pharmacology, Faculty of Medicine, University of Hong Kong, 5 Sassoon Road, Hong Kong;(2) Present address: New York State Research Institute for Neurochemistry and Drug Addiction, 10035 Ward's Island, New York, USA |
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| Abstract: | Summary A new histidine decarboxylase inhibitor, thiazol-4-ylmethoxyamine (TMA), injected into mice in a dose of 100 mg/kg i.p. 48 h before the implantation of a morphine-containing pellet, inhibited the development of morphine tolerance and physical dependence.I thank the World Health Foundation (Hong Kong) for a grant in aid of this research. |
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