Thrombospondins: from structure to therapeutics |
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| Authors: | C. B. Carlson J. Lawler D. F. Mosher |
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| Affiliation: | (1) The Midwest Center for Structural Genomics and Structural Biology Center, Biosciences Division, Argonne National Laboratory, Argonne, IL, USA;(2) Division of Experimental Pathology, Department of Pathology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., EC/CLS-503, Boston, MA 02215, USA;(3) Harvard Medical School, Boston, MA, USA; |
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| Abstract: | Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins has revealed unique and interesting protein motifs. Here, we review this progress and discuss implications for function. By combining structures of modules from thrombospondins and related extracellular proteins it is now possible to prepare an overall model of the structure of thrombospondin-1 and thrombospondin-2 and discern features of other thrombospondins. (Part of a multi-author Review) |
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