| 无溶剂条件下有效合成2,3-二氢-4(1H)-喹唑啉酮衍生物 |
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| 引用本文： | 许碧晖,夏盛,荣良策.无溶剂条件下有效合成2,3-二氢-4(1H)-喹唑啉酮衍生物[J].徐州师范大学学报(自然科学版),2011(3):62-65. |
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| 作者姓名： | 许碧晖 夏盛 荣良策 |
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| 作者单位： | 徐州师范大学化学化工学院; |
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| 基金项目： | 江苏省高校自然科学基金资助项目(08KJB150017) |
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| 摘 要： | 以靛红酸酐、芳醛和芳胺为原料,氢氧化钠为催化剂,在无溶剂条件下加热反应,有效地合成2,3-二氢-4(1 H)-喹唑啉酮衍生物.研究表明,芳醛的环上无论是吸电子基(如卤原子),还是给电子基(如甲基或甲氧基),对反应都没有明显的影响,产物的产率较高,在81%～93%之间.与已有的合成方法相比,本方法具有反应时间短、条件温和、处理简单和环境友好等优点.
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| 关 键 词： | 4(1H)-喹唑啉酮 靛红酸酐 无溶剂合成 绿色化学 |
An efficient synthesis of 2,3-dihydro-4(1H)-quinazolinone derivatives under solvent-free condition |
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| Xu Bihui,Xia Sheng,Rong Liangce.An efficient synthesis of 2,3-dihydro-4(1H)-quinazolinone derivatives under solvent-free condition[J].Journal of Xuzhou Normal University(Natural Science Edition),2011(3):62-65. |
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| Authors: | Xu Bihui Xia Sheng Rong Liangce |
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| Institution: | Xu Bihui,Xia Sheng,Rong Liangce(School of Chemistry & Chemical Engineering,Xuzhou Normal University,Xuzhou 221116,Jiangsu,China) |
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| Abstract: | An efficient method for the preparation of 2,3-dihydro-4(1H)-quinazolinone derivatives by the one-pot reaction of isatiocanhydride,aromatic aldehydes,aromatic amine,in the presence of sodium hydroxide under solvent-free condition is reported.In this study,it is found that,neither bearing electron-withdrawing groups(such as halide) nor electron-donating groups(such as methyl group and methoxyl group) at the rings of aromatic aldehydes have significant effect on this reaction,and the products were gained with... |
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| Keywords: | 4(1H)-quinazolinone isatiocanhydride solvent-free synthesis green chemistry |
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