Tissue distribution and nucleic acid binding of chlorambuci-3H in tumor-bearing rats |
| |
| Authors: | K D Tew D M Taylor |
| |
| Institution: | (1) Radiopharmacology Department, Institute of Cancer Research, SM2 5PT Sutton, (England);(2) Present address: Department of Medical Oncology, Georgetown University, 3800 Reservoir Road, NW, 20007 Washington DC, USA |
| |
| Abstract: | Summary In tumour and normal rat tissues prolonged alkylation of DNA and RNA by chlorambucil-3H occurs over periods of 24 h. It is suggested that this may indicate the slow release of an alkylating moiety from an intracellular drugmacromolecule complex. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
