稀土掺杂纳米二氧化钛染毒对大鼠生化指标的影响

探讨了稀土铈掺杂纳米二氧化钛(纳米TiO2、Ce/TiO2和CeO2/TiO2)经口长期染毒对大鼠血清生化指标的影响。方法:以每只0.15 g/kg的初始剂量给大鼠灌胃染毒,每4天递增1.5倍剂量,共染毒28 d。采集测定各组大鼠第4、16、28 d血清生化指标的变化。结果:长期毒性第4和16 d TiO2、Ce/TiO2和CeO2/TiO2三组大鼠血清生化AST和LDH活力明显高于对照组(P<0.05)。长期毒性的第28 d Ce/TiO2和CeO2/TiO2三组大鼠血清生化ALT活力明显高于对照组(P<0.05),Ce/TiO2组大鼠血清的BUN活力明显高于对照组(P<0.05)。结论:纳米TiO2、Ce/TiO2和CeO2/TiO2长期染毒对大鼠血清LDH、AST、ALT活力及BUN水平有不同程度的影响,与其他两组相比,纳米TiO2组对大鼠生化指标的影响最小。

Effect of oral ingested rear-earth doped Nano-TiO2 on serum biochemical indexes in mice

Objective:To explore the effect of rear-earth doped nano-titanium dioxide(nano-TiO2、Ce/ TiO2 and CeO2/ TiO2) on serum biochemical indexes in mice.Methods:The mice were treated by oral dose of nano-TiO2,Ce/ TiO2 and CeO2/ TiO2 powder at 0.15 g/ kg body weight at first,then add 15 times dose every 4 days,After 28 days the mice were sacrificed.and the serum were collected for biochemical analysis at 4、16、28 day.Results In the 4th and 16th day,the serum LDH and AST of three group were significantly higher than that of control(P<0.05).In the 28th day,the serum ALT of Ce/ TiO2 and CeO2/TiO2 group were significantly higher than that of control(P<0.05).And the serum BUN of Ce/ TiO2 group were significantly higher than that of control(P<0.05).Conclusions:The effect of nano-TiO2,Ce/ TiO2 and CeO2/ TiO2 on mice serum LDH,AST and BUN may be different from each other,nano-TiO2 is the least one.