| 油橄榄叶提取物对铅中毒小鼠心肌乳酸脱氢酶活性和抗氧化能力的影响 |
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| 引用本文： | 王昱.油橄榄叶提取物对铅中毒小鼠心肌乳酸脱氢酶活性和抗氧化能力的影响[J].首都师范大学学报(自然科学版),2013,34(3):34-36,42. |
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| 作者姓名： | 王昱 |
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| 作者单位： | 陇南师范高等专科学校生物系,甘肃成县,742500 |
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| 基金项目： | 甘肃省教育厅科研资助项目 |
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| 摘 要： | 目的:探讨油橄榄叶提取物(OLE)对铅中毒小鼠心肌乳酸脱氢酶活性和抗氧化能力的影响.方法:选健康小鼠,每日灌胃醋酸铅溶液的同时灌胃不同剂量的OLE进行治疗,连续用药30 d,检测心肌乳酸脱氢酶(LDH)、超氧化物歧化酶(SOD)、谷胱苷肽过氧化物酶(GSH-PX)活性和丙二醛(MDA)含量.结果:与模型对照组相比,小鼠灌胃OLE后心肌SOD和GSH-PX活性升高,LDH活性和MDA含量降低.结论:OLE对铅中毒小鼠有一定的疗效,能影响心肌ATP酶活性和抗氧化能力,阻止铅对心肌的毒性.
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| 关 键 词： | 油橄榄叶提取物 铅 心肌 LDH 抗氧化能力 小鼠 |
Effects of Olive Leaf Extract on Level of TDH and Antioxidant Capacity of Myocardium in Lead Poisoned Mice |
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| Wang Yu.Effects of Olive Leaf Extract on Level of TDH and Antioxidant Capacity of Myocardium in Lead Poisoned Mice[J].Journal of Capital Normal University(Natural Science Edition),2013,34(3):34-36,42. |
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| Authors: | Wang Yu |
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| Institution: | Wang Yu (Department of Biology, Longnan Teachers College, Chengxian Gansu 742500) |
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| Abstract: | Objective： To study the effects of olive leaf extract （OLE） on levels of LDH and antioxidant capacity of myocardium in lead poisoned mice. Methods： The health mice were chosen and administered intragastrically with lead acetate and with different dose of OLE for 30 days. The levels of LDH, SOD, MDA, and GSH-PX were detected. Results： Compared with model group, the levels of SOD and GSH-PX tended to be elevated, while the levels of LDH and MDA seemed to be reduced in OLE groups. Conclusion： OLE has significant effects on myocardial LDH activity and antioxidant capacity to protect lead toxicity in myocardiam. |
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| Keywords: | olive leaf extract lead myocardium LDH antioxidant capacity mice |
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