Slow current changes underlying square shaped potential waves in warmedAplysia neurones

Summary On warming, the regularly firing L₁₁ neurone ofAplysia turns into a bursting-type neurone. The bursts of spikes are produced by slow square waves which can also be obtained at room temperature by adding TTX or Co⁺⁺. Experiments with slow ramp voltage clamp show that warming induces a negative slope (or negative resistance) on the current-voltage characteristic and very slow current variations (=10 to 50 sec) in response to potential changes. The square waves are explained by these two phenomena.