原位辅助性部分肝移植

 自1989年原位辅助性部分肝移植成功应用于临床治疗急性肝功能衰竭以来，适应证逐渐扩大至肝功能衰竭、遗传代谢疾病、终末期肝硬化。随技术不断进步趋于成熟，并发症发生率显著降低，远期存活率明显上升，对部分疾病治疗效果达到甚至优于原位肝移植术，并衍生出多米诺原位辅助性部分肝移植等新术式，显著拓展了供体来源及受益人群，成为肝脏疾病重要的治疗手段。本文介绍原位辅助性部分肝移植术的发展历程及研究进展。

Auxiliary partial orthotopic liver transplantation

Since the auxiliary partial orthotopic liver transplantation (APOLT) was successfully applied as a clinical treatment for the acute liver failure in 1989, the indication of APOLT has been gradually expanded to the liver failure, the metabolic liver disease and the endstage liver cirrhosis. With the surgical technique gradually coming to a mature stage, the postoperative complication rate is significantly reduced and the long-term survival outcome sees an encouraging up-trend. In selected patients such as those of acute liver failure, APOLT even offers an advantage over the orthotopic liver transplantation, which was regard as the standard for these diseases. The emergence of new types of APOLT such as the Domino APOLT and the Cross-Domino APOLT will significantly expand the donor source and the beneficiaries. The APOLT has become an important treatment of liver diseases.