电子尼古丁传送系统安全评价及风险评估

 电子尼古丁传送系统（ENDS）具有成分简单、烟碱含量可控等优点，被认为是一种理想的卷烟有效替代品。由于电子尼古丁传送系统在尼古丁释放过程中不发生燃烧，可降低烟雾中的有害成分，被认为可降低对吸烟者造成的危害。为进一步认识ENDS，本文综述了其使用中可能面临的DNA损伤及典型有害成分亚硝胺和苯并a]芘的致突变性等问题。从化学分析、毒理学、细胞暴露、动物实验和临床研究5个方面讨论了ENDS的风险性，并对ENDS的发展进行了展望。

Safety assessment methods and risk evaluation for electronic nicotine delivery system

Electronic nicotine delivery system (ENDS) has the advantage of chemically simple and nicotine contents controllable, and is considered to be the ideal substitute for cigarette. Meanwhile, ENDS is marketed as less harmful alternatives to cigarette because of not burning in the nicotine delivery process and less harmful chemical components in vapor. To deeply study ENDS, DNA damage and mutation caused by tobacco specific nitrosamines (TSNAs) and benzo(a)pyrene in ENDS vapor are reviewed in this paper. Risk evaluation of ENDS in chemical analysis, toxicology, cell exposure, animals experiments and clinical research are also discussed. Finally, the future development of ENDS is prospected.