核受体Rev-erbs的能量稳态调控作用及其运动科学研究展望

 核受体Rev-erbs是能量稳态调控的核心转录调节因子，其表达受饮食、药物、运动等因素的影响；Rev-erbs参与糖脂代谢、胰岛素分泌、血糖稳态调节等多个生物学过程，是肥胖症、糖尿病等慢性代谢性疾病治疗的重要药物靶标，通过调节糖脂代谢通路中的靶分子，调控组织的能量稳态。运动干预刺激肝脏、骨骼肌等组织中Rev-erbs表达，调控糖脂代谢基因，维持细胞能量稳态，可能是慢性病运动干预的重要适应机制。简述了Rev-erbs的结构特点、表达调控因素与作用机制，分析了运动干预对Rev-erbs表达的影响与代谢调控机制，以及Rev-erbs在运动科学领域的国际前沿和发展趋势。

A review on regulation of Rev-erbs in energy homeostasis and research prospect in sports science

Nuclear receptor Rev-erbs have mainly two subtypes, Rev-erbα and Rev-erbβ, which are widely expressed but mainly prevalent in tissues and organs of mammalians that have predominantly metabolic functions. The expression level of Rev-erbs can be influenced by various factors such as high calorie diet, medicine, and exercise intervention. Rev-erbs are essential to regulate glucose and lipid metabolism, insulin secretion, and blood glucose homeostasis, and are the therapeutic target of chronic diseases such as obesity and diabetes. Rev-erbs may maintain energy homeostasis through related signaling pathway of glucose and lipid metabolism. Recent researches indicate that exercise regiments stimulate Rev-erbs expressions in liver and skeletal muscle and maintain lipid homeostasis, which would be the core mechanism of exercise intervention to chronic diseases. This review analyzes the bioactivity and the mechanism of Rev-erbs, and proposes future studies on Rev-erbs in the sphere of sports science.