白芥子对蛇床子体外经皮渗透的影响

探讨白芥子促透皮吸收的物质基础.以蛇床子为研究对象,采用改良Franz扩散池,以离体Wistar大鼠背部皮肤为透皮模型,考察白芥子中白芥子碱、白芥子苷和黄酮、白芥子多糖、白芥子脂肪油、白芥子挥发油及不同促渗剂对蛇床子中蛇床子素体外经皮渗透的影响.结果表明,白芥子中挥发油和不同促渗剂均能促进蛇床子素经皮吸收,其作用强弱依次为5%薄荷油(17.842 9μg·cm-2·h-1)5%冰片(17.004 2μg·cm-2·h-1)5%氮酮(16.656 0μg·cm-2·h-1)0.5%白芥子挥发油(16.610 1μg·cm-2·h-1).白芥子中挥发油对蛇床子中蛇床子素具有促透皮吸收作用,百分含量以0.5%为最佳.

Effect of Semen Sinapis on percutaneous permeation of Cnidium monnieri in vitro

To investigate the material basis of Semen Sinapis promoting percutaneous absorp-tion, the Cnidium monnieri was taken as the research object .The penetration experiments in vitro were performed using excised dorsum skin of Wistar rats on modified Franz diffusion cells to study the effect of Semen Sinapis alkali , Semen Sinapis glycosides and flavonoids , Semen Sinapis polysaccharide , Semen Sinapis fatty oil , Semen Sinapis volatile oil from Se-men Sinapis and several penetration enhancers on percutaneous permeation of Osthole .Re-sults indicated that the penetration rate of Osthole by the volatile oil from Semen Sinapis and several penetration enhancers was increased in the following order：5%peppermint oil （17. 842 9 μg· cm-2 · h -1 ）〉5%borneol （17.004 2 μg· cm -2 · h -1 ）〉5%azone （16.656 0μg· cm-2· h-1）〉0.5% volatile oil from Semen Sinapis（16.610 1 μg· cm -2· h-1）. The volatile oil from Semen Sinapis can improve the percutaneous absorption of Osthole from Cnidium monnieri , and the concentrations of 0.5%had the best effect .