| 尿嘧啶替加氟片溶出度方法的考察 |
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| 引用本文： | 马宏宇,成秉辰,尹燕杰. 尿嘧啶替加氟片溶出度方法的考察[J]. 哈尔滨商业大学学报(自然科学版), 2014, 0(5): 539-541 |
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| 作者姓名： | 马宏宇 成秉辰 尹燕杰 |
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| 作者单位： | 哈尔滨市食品药品检验检测中心,哈尔滨,150525 |
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| 摘 要： | 建立尿嘧啶替加氟片中替加氟和尿嘧啶的溶出度方法.采用转篮和浆法,以水为溶出介质,采用高效液相色谱法测定尿嘧啶替加氟片溶出度.结果表明,两种方法均可使尿嘧啶替加氟片二个组分很快溶出,30 min时二个组分的累积溶出量均达到75%以上,但方法之间存在差异.浆法更适合用于尿嘧啶替加氟片溶出度的测定.
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| 关 键 词： | 高效液相色谱法 尿嘧啶替加氟片 溶出度 |
Study on dissolution test of compound tegafur tablets |
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| MA Hong-yu,CHENG Bing-chen,YIN Yan-jie. Study on dissolution test of compound tegafur tablets[J]. Journal of Harbin University of Commerce :Natural Sciences Edition, 2014, 0(5): 539-541 |
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| Authors: | MA Hong-yu CHENG Bing-chen YIN Yan-jie |
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| Affiliation: | ( Harbin Testing Center for Food and Drug, Harbin 150525) |
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| Abstract: | This paper established a test method for the dissolution of tegafur and uracil in compound tegafur tablets .Using basket and paddle method , the dissolution was tested by HPLC method , and the medium was water .The results indicated that tegafur and uracil in compound tegafur tablets were dissolved rapidly in two dissolution conditions , and the disso-lution rate of 30 min of all of the formations showed advantage than 75%of labeled amount . But they are a little diffrentent .The method of apparatus 2 was suitable for the determmina-tion of the dissolution of compound tegafur tablets . |
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| Keywords: | HPLC compound tegafur tablets dissolution |
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