| 吲哚-2,3-环氧的酸开环反应 |
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| 引用本文： | 傅凯,张振国,郭晶晶,荀苗苗,袁长春.吲哚-2,3-环氧的酸开环反应[J].四川大学学报(自然科学版),2023,60(2):025001-142. |
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| 作者姓名： | 傅凯 张振国 郭晶晶 荀苗苗 袁长春 |
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| 作者单位： | 中北大学化学与化工学院化工综合国家级实验教学示范中心,中北大学化学与化工学院化工综合国家级实验教学示范中心,中北大学化学与化工学院化工综合国家级实验教学示范中心,中北大学化学与化工学院化工综合国家级实验教学示范中心,中北大学化学与化工学院化工综合国家级实验教学示范中心 |
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| 基金项目： | 山西省自然科学(201901D211220) |
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| 摘 要： | 以吲哚-2,3-环氧化合物和商品化的酸为主要反应物，经环氧的酸开环反应，可以高收率地得到一系列的酯基取代的二氢吲哚化合物.该方法简便高效，首次实现了吲哚-2,3-环氧化合物在酸性条件下的开环反应，为酯基取代的吲哚化合物的合成提供了一种新的合成方法.
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| 关 键 词： | 吲哚-2 3-环氧化合物 环氧 酸 开环反应 |
| 收稿时间： | 2022/10/4 0:00:00 |
| 修稿时间： | 2022/11/11 0:00:00 |
The ring opening reaction of indole-2,3-epoxides with acid |
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| FU Kai,ZHANG Zhen-Guo,GUO Jing-Jing,XUN Miao-Miao and YUAN Chang-Chun.The ring opening reaction of indole-2,3-epoxides with acid[J].Journal of Sichuan University (Natural Science Edition),2023,60(2):025001-142. |
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| Authors: | FU Kai ZHANG Zhen-Guo GUO Jing-Jing XUN Miao-Miao and YUAN Chang-Chun |
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| Institution: | National Demonstration Center for Experimental Chemical Engineering Comprehensive Education,School of Chemistry and Chemical Engineering,National Demonstration Center for Experimental Chemical Engineering Comprehensive Education,North University of China,National Demonstration Center for Experimental Chemical Engineering Comprehensive Education,School of Chemistry and Chemical Engineering,National Demonstration Center for Experimental Chemical Engineering Comprehensive Education,North University of China,National Demonstration Center for Experimental Chemical Engineering Comprehensive Education,School of Chemistry and Chemical Engineering,National Demonstration Center for Experimental Chemical Engineering Comprehensive Education,North University of China,National Demonstration Center for Experimental Chemical Engineering Comprehensive Education,School of Chemistry and Chemical Engineering,National Demonstration Center for Experimental Chemical Engineering Comprehensive Education,North University of China,National Demonstration Center for Experimental Chemical Engineering Comprehensive Education,School of Chemistry and Chemical Engineering,National Demonstration Center for Experimental Chemical Engineering Comprehensive Education,North University of China |
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| Abstract: | A series of dihydroindoles 3-ester substituted compounds can be obtained in high yield by the acid ring-opening reaction of epoxy using indole-2,3-epoxy compounds and commercial acids as the main reactants. This method is simple and efficient, and it is the first time to realize the ring opening reaction of indole-2,3-epoxy compounds under acidic conditions, which provides a new synthesis method for the synthesis of ester substituted indole compounds. |
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