Chiral N-formyl amino alcohol as Lewis basic organocatalyst for enantioselective hydrosilylation of ketimines |
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| Authors: | ZhouYu Wang Li Zhou XiaoXia Lu Jian Sun |
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| Affiliation: | 1 Natural Products Research Center, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
2 Department of Pharmaceutics Engineering, Xihua University, Chengdu 610039, China |
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| Abstract: | Easily accessible (1R,2S)-1,2-diphenyl-2-formamidoethanol has been developed as an effective Lewis base catalyst in the enanti-oselective hydrosilylation of ketimines, affording high isolated yields (up to 94%) and moderate to high enantioselectivities (up to 82% ee) for a broad range of ketimines. |
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| Keywords: | N-formyl amino alcohol Lewis base organocatalyst imine asymmetric reduction |
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