肠道菌群在肥胖及相关的代谢性疾病发生发展中的地位和作用

肥胖及相关的代谢性疾病近年来已经成为威胁全球的公共健康问题。越来越多的证据表明,与人类共生的肠道菌群不仅在消化、免疫和抗病方面有不可替代的作用,而且与非传染性的代谢失调相关,特别是其可以通过调节宿主脂肪吸收存储相关的基因,影响后者的能量平衡。因此,肠道菌群可能是在膳食结构变化与人的遗传体质的相互作用下导致肥胖等代谢性疾病发生的一个重要环节。对该环节的深入研究,可能带来代谢性疾病预防和控制策略的革命性的变化。

Unraveling the roles of Gut microbiota in predisposition to and progression of obesity and related metabolic disorders

The prevalence of obesity-related metabolic disorders has become a challenge to public health around the world. Recent evidences indicates that gut microbiota can help digest otherwise undigestible food components and regulate host fat storage genes, may thus play an important mediating role between diet, life style and host genetics in development of obesity and eventually many forms of metabolic diseases. Research along this line may lead to discovery of new therapeutic targets and revolutionary strategies for predictive, preventive and personalized management of metabolic disorders.