| Monoclonal Anti-CD4 Antibody MT310 Binds HIV-1 gp120 Binding Site on CD4 |
| |
| 引用本文： | 秦莉,朱梅,陈应华. Monoclonal Anti-CD4 Antibody MT310 Binds HIV-1 gp120 Binding Site on CD4[J]. 清华大学学报, 2001, 0(3) |
| |
| 作者姓名： | 秦莉 朱梅 陈应华 |
| |
| 作者单位： | QIN Li，ZHU Mei，Gert Riethmuller ，Peter Rieber ，CHEN Yinghua ** Laboratory of Immunology，Research Center for Medical Science，Department of Biological Sciences and Biotechnology，Tsinghua University，Beijing 100084，China; Institute |
| |
| 基金项目： | Munich University in Germany and theNational Key Basic Research Specific Funds of China(No.G19990 75 6 0 7) |
| |
| 摘 要： | IntroductionHuman immunodeficiency virus type1 ( HIV- 1 ) ,after binding by the envelope protein gp1 2 0 to itscellular receptor CD4,enters susceptible cellsthrough p H- independent fusion[1,2 ] . The sitewhich HIV- 1 gp1 2 0 binds is located in the firstdomain on the CD4molecule[3 5] .The anti- CD4m Ab Leu3a recognizes the gp1 2 0 binding site onCD4[6] and the anti- CD4m Ab MT31 0 stronglyinhibits HIV- 1 infection of CD4+ T cells,while theanti- CD4 m Ab MT1 5 1 weakly inhibitsinf…
|
Monoclonal Anti-CD4 Antibody MT310 Binds HIV-1 gp120 Binding Site on CD4 |
| |
| Abstract: | |
| |
| Keywords: | anti idiotypic antibody epitope analysis anti CD4 antibody |
| 本文献已被 CNKI 等数据库收录！ |
