Brominated benzene induction of hepatic porphyria

Summary Unlike the highly porphyrinogenic fungicide hexachlorobenzene, hexabromobenzene was a poor inducer of porphyria. Similarly, 1,2-dibromobenzene and 1,2,4-tribromobenzene, while causing small increases in hepatic porphyrins, did not increase ALA synthetase or the urinary excretion of porphobilinogen (PBG), aminolevulinic acid (ALA) or porphyrins.Supported by grant R805070 from the US Environmental Protection Agency.