| 苯胺法制备D-青霉胺 |
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| 引用本文： | 张倩影,蒋海珍,浦家齐.苯胺法制备D-青霉胺[J].上海大学学报(自然科学版),2002,8(5):456-458,462. |
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| 作者姓名： | 张倩影 蒋海珍 浦家齐 |
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| 作者单位： | 上海大学,理学院,上海,200436 |
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| 摘 要： | 对D－青霉胺的合成进行了研究。将青霉素G钾盐溶解于水中，再依次加入甲苯和冰醋酸，室温下搅拌片刻后，加入苯胺，在氮气保护下，加热回流5h，一步反应生成了D－青霉胺，所得的产品结构由核磁共振谱和比旋光度确认，D－青霉胺的产率为64％。
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| 关 键 词： | 苯胺法 制备 青霉素 D－青霉胺 合成方法 重金属离子中毒 免疫抑制作用 抗炎作用 |
| 文章编号： | 1007-2861(2002)05-0456-03 |
Preparation of D-Penicillamine Using Aniline |
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| ZHANG Qian ying,JIANG Hai zhen,PU Jia qi.Preparation of D-Penicillamine Using Aniline[J].Journal of Shanghai University(Natural Science),2002,8(5):456-458,462. |
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| Authors: | ZHANG Qian ying JIANG Hai zhen PU Jia qi |
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| Abstract: | D Penicillamine was prepared successfully by a single step reaction. Under nitrogen, benzylpenicillin potassium salt was dissolved in a mixture of water, toluene and acetic acid. Stirring was carried out at room temperature for a few minutes and aniline was then added. The product was obtained under refluxing for additional five hours. Structure and purity of the product were confirmed by 1 H NMR and specific rotatory power. The yield of D Penicillamine was 64%. |
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| Keywords: | benzylpenicillin D penicillamine synthesis |
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